Guideline on allergen-specific immunotherapy in IgE-mediated allergic diseases
نویسندگان
چکیده
O L I V E R PFA A R1, 2, CL AUS BAC H E R T3, AL B R E C H T BU FE 4, RO L A N D BU H L 5, CH R IS TO F EB N E R 6, PE T E R EN G7, FR A N K FR I E D R I C HS 8, TH O M A S FU C HS 9, EC K A R D HA M E L M A N N10, DO R IS HA R T W I G-BA D E11, TH O M A S HE R I N G12, IS I D O R HU T T E G G E R13, K I R S T E N JU N G14, LU D G E R K L I M E K1, MAT T H I A S VO L K M A R KO PP15, HA NS ME R K16, UTA R A B E17, JOAC H I M SA LO G A18, PE T E R SC H M I D -G R E N D E L M E I E R19, AN TJ E SC H US T E R 20, NI CO L AUS SC H W E R K 21, HE L M U T SI T T E R 22, UL R I C H UM PFE N BAC H 23, BE T T I N A WE D I24, ST E FA N WÖ H R L 25, MA R G I T TA WO R M 26, JÖ R G K L E I N E-TE B B E 27 CO M M E N T I N G PA R T I C I PA N T S A N D FAC I L I TATO R S: SUSA N N E K AU L 28, AN JA SC H WA L FE N B E R G 29
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Recent Progress in Allergen Immunotherapy
The efficacy of allergen immunotherapy for the treatment of allergic rhinoconjunctivitis with or without seasonal bronchial asthma and anaphylaxis caused by the sting of the hymenoptera class of insects has been clearly demonstrated in numerous well-designed, placebo-controlled trials. Immunotherapy whether by subcutaneous injection of allergen extract or by oral/sublingual routes modifies peri...
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Allergen Immunotherapy (AIT), is effective in reducing the clinical symptoms associated with allergic rhinitis, asthma and venom induced anaphylaxis [1]. Subcutaneous (SCIT) and Sublingual (SLIT) with unmodified allergen extracts are the two routes of administration of allergen vaccines. In addition, AIT has been positioned as the only treatment that may alter the natural course of allergic dis...
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This Guideline replaces the Note for Guidance on " Allergen products " (CPMP/BWP/243/96). This Guideline lays down the quality recommendations for allergen products of biological origin, including allergen extracts derived from natural source material and allergens produced through recombinant DNA technology, used for specific immunotherapy (SIT) or in vivo diagnosis of immunoglobulin E (IgE)-m...
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Allergic diseases represent a complex innate and adoptive immune response to natural environmental allergens with Th2-type T cells and allergen-specific IgE predominance. Allergen-specific immunotherapy is the most effective therapeutic approach for disregulated immune response towards allergens by enhancing immune tolerance mechanisms. The main aim of immunotherapy is the generation of allerge...
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Allergen specific immunotherapy (ASIT) is the only disease modifying treatment of allergic diseases. A key element in the protective effect is thought to be induction of a specific IgG4 response leading to a decrease in the IgE-mediated allergic symptoms. The effect of ASIT can be ascertained by provocation or skin prick testing. IgE measurement by ImmunoCAP is a sensitive standard procedure fo...
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